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A Revolutionary Strategy for Reversing Type-2 Diabetes

Diabetes is one of the most common diseases in the world. It is also a condition which has doctors and health officials incredibly worried. The reason for this is the fact that the disease has been considered an epidemic, with more and more people being diagnosed now, than ever before. Currently there are close to 30 million people suffering from diabetes in the United States alone, with more and more cases being reported in other parts of the developed world.

Type-2 Diabetes is by far the most common form of the disease, with 9 out of every 10 people affected by diabetes having Type-2, as opposed to Type-1. The good news is that it can be prevented or even reversed. In this article, we’re going to take a look at a revolutionary strategy, which many scientists believe could be the key to reversing Type-2 Diabetes permanently.

Why Treatments Fail in Type II Diabetes?

Currently, all forms of diabetes treatment are focused upon reducing patients’ blood sugar levels. While these treatments are essential, experts have found that they aren’t sufficient. Indeed, even when blood sugar levels have been constantly controlled, scientists have noticed patterns setting in, whereby after a while, drugs and medications gradually lose their effects, despite having worked fine for a few years. Once this happens, patients will then have to take two or more medications to regulate their blood sugar levels. This is far from ideal because they often present side effects and eventually, they too become ineffective. When this happens, insulin injection becomes inevitable, and nobody wants that. It is obvious that some important things have been missing or neglected in current treatment options.

Maintaining Healthy beta Cell Function Is the Key

Type-2 Diabetes is a condition whereby pancreatic beta cells are still producing insulin, but they are not producing enough. Despite having long been considered a hallmark of type 2 diabetes, insulin resistance alone does not lead to the onset of diabetes. Indeed, the symptoms caused by insulin resistance appear only after 50% or more of beta cells have lost their function. Hence, healthy beta cell function means that insulin resistance is not an issue. If beta cell health begins to suffer however, insulin resistance, or insufficient insulin secretion, becomes a real concern, and can result in Type-2 Diabetes.

 

How beta Cells Become Damaged?

By now we’ve established that healthy beta cell function is the key to avoiding diabetes, but how do they become damaged, lose their function, and die completely? The two most common causes of beta cell damage are ER (Endoplasmic Reticulum) stress, and Oxidative stress within the cells themselves. Unfortunately, current medications have not been able to resolve these two issues.

ER stress is mainly caused by the build-up of misfolded proinsulin within the ER of a beta cell. The misfolded proinsulin is highly toxic and causes beta cells to die off entirely. Once beta cells die, they’re gone, so they are no longer able to synthesize insulin.

Oxidative stress is caused by oxidative species (and partly by the ER stress) located within the beta cells. These reactive oxygen species attack the beta cells by oxidizing almost everything, including the DNA of the beta cells. Oxidation is why food located within our freezers turns bad after a while, due to exposure to oxygen. A piece of meat turning rancid in your fridge is basically what happens to your beta cells when they are exposed to oxidative stress. Unfortunately, beta cells are extremely sensitive to oxidative stress.

Both the above factors combined can induce apoptosis and rapidly speed up beta cell mass destruction, resulting in a severe disruption to beta cell homeostasis.

Endoplasmic Reticulum associated Degradation

Endoplasmic Reticulum Associated Degradation is a natural physiological process which specifically targets and removes harmful misfolded proinsulin from the ER of beta cells. Since Endoplasmic reticulum associated degradation can prevent misfolded proinsulin from accumulating in the ER, it ameliorates ER stress and indirectly, the oxidative stress. Just how efficient Endoplasmic reticulum associated degradation  is however, is believed to be down to genetics. What’s more, the body’s ability to remove reactive oxygen species is also determined by genetics. If you’re lucky, genetically-speaking, you could have a lower risk of getting diabetes, if you don’t abuse your body. However, if you are not that lucky, you may try to enhance your Endoplasmic reticulum associated degradation, which has not been addressed by your current medication.

Restoring beta cell function

In people with type II diabetes, the insulin-producing β cells and the diabetic medications collaboratively  regulate the blood sugar levels. As you may expect over time, to maintain the same level of blood sugar, stronger medications are needed as the β cell mass diminishes. For those of you looking to prevent, or even reverse, Type-2 Diabetes, restoring beta cell homeostasis is essential.  After all, to maintain the same level of blood sugar, the stronger your β cells are, the less medications you need. Tactics, including enhancing Endoplasmic reticulum associated degradation and removing free radicals and oxidative species from the beta cells should be useful. By doing this, you are acquiring what you have been missing in the treatments that are currently available for diabetes, and as a result, beta cell death rates will slow down dramatically, while the body is generating new and healthy beta cells.

Managing Diabetes

Finally, before we wrap things up, we’re going to talk to you about what you can do to manage your diabetes. These include:

Medications – As mentioned, eventually the body builds up a resistance to oral diabetes medications, in which case insulin injection will need to be carried out daily. However, that does not mean that the currently available medications are not effective. Even high dosage or a cocktail may be needed to be effective. However, they all directly help maintain your blood sugar level. As prolonged hyperglycemia causes serious complications, prescribed medications are essential.

Synergists that reduce ER and Oxidative Stress – As beta cell homeostasis has not been addressed by regular diabetic medicines, taking synergists that help reduce the ER stress and oxidative stress may be another smart approach for people to manage their diabetes.

Healthy lifestyle – When it comes to treating diabetes, especially for people who are pre-diabetic, nothing is more important than leading a healthy lifestyle. Don’t eat or drink sugary foods, cut out excessive junk food, get plenty of exercise, drink water, and try to manage your weight and maintain it at a healthy level.