ERAD Plus® is designed for people seeking to improve their general wellness for a healthier aging process.
Endoplasmic Reticulum-associated Degradation is a very important cellular survival mechanism that handles problematic (or misfolded) proteins in our bodies. Well-known problematic proteins that cause diseases include β-amyloid, misfolded insulin (as proinsulin), alpha-synuclein and so on (1). Like that misfolded β-amyloid causes Alzheimer's Disease, accumulation of misfolded insulin in the Endoplasmic Reticulum (ER) results in ER Stress, which consequently kills physiologically important cells by initiating apoptosis. In fact, ER stress has been recognized as the top leading cause of unwanted cell death.
ERAD machinery in our cells can specifically target misfolded or unfolded proteins such as insulin for degradation. Once a misfolded protein is targeted by cellular ERAD machinery, it will be removed from the ER and sent to the cytoplasm for degradation by the proteasome. As the cause of ER Stress can be ameliorated, ERAD has been considered a therapeutic target for many diseases (2).
The ERAD Plus® series is the first natural supplement in the world that can help maintain healthy levels of ER Stress and Oxidative Stress by enhancing ERAD.
ERAD Plus® Original is not only designed for people seeking to improve their general wellness (see details) for a healthier aging process. As the ingredients act in synergism with a healthy lifestyle and prescribed diabetic medications, ERAD Plus® Original is particularly beneficial to people with type 2 diabetes.
- Yoshida H. ER Stress and Diseases. FEBS J. 2007 Feb;274(3):630-58.
- Guerriero CJ and Brodsky JL. The delicate balance between secreted protein folding and endoplasmic reticulum-associated degradation in human physiology. Physiol Rev. 2012 Apr; 92(2): 537–576.
ERAD Plus™ Original includes:
- All-natural ingredients.
- A proprietary herbal blend (ERAD Plus™) which has been shown in laboratories to enhance a physiological process called Endoplasmic Reticulum-associated Degradation that is able to maintain healthy ER stress levels in pancreatic beta cells*
- Herbal extract that activates AMPK to promote healthy metabolism*
- Proprietary bioflavonoids as anti-oxidants to promote healthy levels of oxidative stress*
Planning to take ERAD Plus® Original
- It is recommended to take for at least 6 weeks continuously.
- Regularly taking Vitamin B Complex is strongly recommended.
- It is best used with healthy diets and regular exercise.
- ERAD Plus® Original may enhance the strength of certain blood thinners.